Clinically, the significance of the determination of urinary creatinine (UC) r is very wide. First of all, due to the relatively constant UCr discharge day and night, less interference factors, is a good way to correct the difference between urine and individual differences. This feature of UCr can assist in the diagnosis of many clinical diseases, such as urinary amylase and UCr ratio in the diagnosis of acute pancreatitis, urinary protein creatinine ratio in the diagnosis of early renal damage in diabetic patients. Secondly, the number of 24 h UCr is related to renal function. Using this feature, 24 UCr h and serum creatinine were measured, and the clearance rate of creatinine clearance (Ccr) of 24 h was calculated. Ccr is one of the commonly used methods in the evaluation of glomerular filtration rate (GFR). Ccr can not only help diagnose and predict the progression of chronic kidney disease, but also provide scientific basis for the selection of treatment options. Third, the determination of 24 h UCR can also reflect the nutritional status of the body, the continuous 3 days 24 h UCR average and same sex and height standard creatinine value to obtain the creatinine height index (CH I), the index is a sensitive index to measure the level of body protein, are widely used in nutritional assessment. Therefore, the accurate determination of UCr is very important.
The reference value of creatinine in urine was: male: D / 5.3-16.0mmol; female: 7.0-18.0mmol / d. And general creatinine determination reagent is linear (0-6000) umol / l around, in order to ensure the urine samples of creatinine values fell within the linear detection range of kit, so as to ensure detection accuracy, so it is necessary to urine samples are diluted. General recommendations are diluted to 20 times as appropriate.